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SUMMARY:Comparative transcriptomics identifies a single SNP mutation that 
 controls virulence of African Salmonella - Jay Hinton\, University of Live
 rpool
DTSTART:20190705T120000Z
DTEND:20190705T130000Z
UID:TALK126358@talks.cam.ac.uk
CONTACT:Dr. Maryam Arasteh
DESCRIPTION:With 3.4 million infections each year\, invasive non-Typhoidal
  Salmonella (iNTS) is a major cause of illness worldwide. In Sub-Saharan A
 frica bloodstream infections with iNTS Salmonella enterica serovar Typhimu
 rium are causing ~388\,000 deaths annually. Co-infection with HIV or malar
 ia in adults\, and a young age (<5 years) are known risk factors.\n\nUsing
  a combination of comparative genomics and comparative transcriptomics\, \
 nwe discovered phenotypic differences that distinguish African from global
  Salmonella pathovariants (Canals et al.\, 2019).\n\nOur analysis led us t
 o identify a single core genome SNP responsible for the up-regulation of a
  single promoter in strain D23580 that controlled the expression of a Salm
 onella virulence factor (Hammarlöf et al.\, 2018)\, and offers part of th
 e explanation of the pan-African epidemic of bloodstream infection.\n\nAll
  of the Salmonella transcriptomic data we have generated are now available
  online in a user-friendly website that allows intra-strain and inter-stra
 in comparisons of gene expression: http://bioinf.gen.tcd.ie/cgi-bin/salcom
 _v2.pl \n\n\nReferences\n\nCanals et al. (2019) Adding function to the gen
 ome of African Salmonella Typhimurium ST313 strain D23580. PLoS Biology 17
 (1): e3000059.\n\nHammarlöf et al. (2018) Role of a single noncoding nucl
 eotide in the evolution of an epidemic African clade of Salmonella. Proc. 
 Nat\, Acad. Sci. USA 115: E2614 - E2623.\n
LOCATION:LMB\, Max Perutz Lecture Theatre  
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