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SUMMARY: Motor planning in the cerebellar system through rebound - Maarten
  Zwart\, University of St Andrews
DTSTART:20190617T110000Z
DTEND:20190617T120000Z
UID:TALK126394@talks.cam.ac.uk
CONTACT:Jimena Berni
DESCRIPTION:Behaviour is often driven by both the current environment and 
 experiences from the recent past. How does the brain integrate these sourc
 es of information? Here\, using whole-brain imaging during behaviour\, we 
 identify an inhibitory brain region in the larval zebrafish dorsal hindbra
 in (DH cells) that integrates stimuli over time. DH cells detect visual in
 put that promotes swimming\, integrate this in ongoing activity\, and dete
 rmine how quickly the animal responds to future stimuli (motor readiness).
  They do this in between actions\, and reset after each movement. Optogene
 tic activation of the DH cells increases motor readiness\, but suppresses 
 current motor output\, suggesting that the DH cells cause a rebound in the
  motor system. We show that DH cells project to the inferior olive\, and c
 onfirm that these cells inhibit this nucleus and cause a rebound upon rele
 ase. Using neuronal network models\, we show that these results imply that
  inhibitory integrators are complementary to integrate-to-bound models for
  sensory integration and motor planning.
LOCATION:First Floor Seminar Room\, Zoology Building
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