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SUMMARY:All kinds of JNK: How one kinase can be an oncogene\, tumour suppr
 essor and apoptotic mediator  - Dr David Croucher\; Group Leader - Network
  Biology\, Garvan Institute of Medical Research\, Australia
DTSTART:20190801T110000Z
DTEND:20190801T120000Z
UID:TALK126412@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The c-Jun N-terminal Kinase (JNK) was originally identified as
  a mediator of stress induced apoptosis\, although it is now known to also
  play contradictory roles as both a key tumour suppressor and potent oncog
 ene. Because of this pleotropic functionality\, targeting JNK directly is 
 unlikely to ever yield successful translation to the clinic. However\, we 
 now show that these distinct functions of JNK emerge from two subcellular-
 specific JNK signalling network states that can exist simultaneously withi
 n breast cancer cells\, with opposing functional and prognostic roles. By 
 utilising a novel protein-protein interaction based proteomics technique\,
  and high content imaging with a JNK biosensor\, we have specifically diss
 ected the signalling complexes that regulate the subcellular activation of
  JNK in breast cancer. Through this analysis\, we now demonstrate that tar
 geting the subcellular activity of JNK represents a viable strategy for sp
 ecifically inhibiting the oncogenic function of JNK\, without impairing it
 s key role as a tumour suppressor.
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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