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SUMMARY:Genome remodelling in Streptococcus pyogenes - Dr Claire Turner (T
 he University of Sheffield)
DTSTART:20191106T160000Z
DTEND:20191106T170000Z
UID:TALK126436@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:I am a Royal Society and Wellcome Trust Sir Henry Dale Researc
 h Fellow. My laboratory is within the Department of Molecular Biology & Bi
 otechnology\, University of Sheffield and is also part of the Florey Insti
 tute for Host Pathogen Interactions. My research group focusses primarily 
 on the pathogenesis of the human pathogen Streptococcus pyogenes through w
 hole genome sequencing (WGS) and in vitro disease modelling. we identified
  a new variant within the genotype emm89 population that emerged having un
 dergone recombination leading to increased NADase and Streptolysin O toxin
  expression and loss of the hyaluronic acid capsule. This new acapsular/hi
 gh-toxin emm89 variant rose rapidly to dominance. More recently\, we also 
 identified that other genotypes have gone through similar genome-remodelli
 ng events towards an acapsular/high-toxin genotype/phenotype. I will prese
 nt our findings and how we think these\, and other\, genetic changes contr
 ibute to the success of new streptococcal variants. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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