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SUMMARY:Nutrition sensing pathways regulate transmission of mutant mitocho
 ndrial genomes - Dr Maulik Patel | Vanderbilt University 
DTSTART:20190729T130000Z
DTEND:20190729T140000Z
UID:TALK126469@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Hundreds to thousands of mitochondrial genome copies are norma
 lly present in each cell. However\, a fraction of these genomes can acquir
 e pathogenic mutations and coexist with wildtype copies. We sought to dete
 rmine the cellular forces that allow mutant genomes to persist. Given the 
 central role of mitochondria in metabolism\, we reasoned that mitochondria
 l genome dynamics might be sensitive to nutritional conditions. Using mode
 l system C. elegans\, we find that mutant genomes lose their competitive a
 dvantage over wildtype genomes within the female germline under conditions
  of caloric restriction. Our subsequent genetic and cellular analyses show
  that this is because mutant genomes sense and exploit nutrition sensing p
 athways. We are currently exploring the molecular mechanisms that underlie
  the ability of mutant genomes to exploit nutrition. Taken together\, our 
 work suggests that environmental context of diet and nutrition can play an
  important role in modulating the mitochondrial genotype.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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