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SUMMARY:Fitness selection in the early mouse embryo: how differences in mi
 tochondrial activity trigger cell competition - Dr Tristan Rodriguez | Imp
 erial College London 
DTSTART:20191030T150000Z
DTEND:20191030T160000Z
UID:TALK126475@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:During the early stages of mammalian development\, the cellula
 r and molecular landscape is profoundly remodelled. As embryonic cells app
 roach gastrulation\, when the precursors of all embryonic tissues are spec
 ified\, they need to rewire the transcriptional\, epigenetic\, metabolic a
 nd signalling networks that govern cell identity. The scale of this remode
 lling creates a large potential for the emergence of abnormal cells that n
 eed to be removed to prevent them from contributing to later development o
 r the germline. Here I will discuss the work my laboratory has done to unr
 avel the mechanism of elimination of these damaged cells. I will present e
 vidence to show that during embryonic differentiation\, cells with a varie
 ty of forms of cellular damage\, from mis-patterning to karyotypical abnor
 malities\, are recognised as a less-fit and eliminated by their neighbours
  through cell competition. Furthermore\, I will discuss the role that diff
 erences in mitochondrial activity has for triggering these competitive int
 eractions as well as the implications that this fitness selection has for 
 regulation of proper embryonic growth.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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