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SUMMARY:Aromatic foldamer based protein mimicry and recognition - Prof. Iv
 an Huc (Ludwig-Maximilians-Universität)
DTSTART:20190704T133000Z
DTEND:20190704T143000Z
UID:TALK126865@talks.cam.ac.uk
CONTACT:Lingtao Kong
DESCRIPTION:Aromatic oligomers constitute a distinct and promising class o
 f synthetic foldamers – oligomers that adopt stable folded conformations
 . Single helical structures are\, to a large extent\, predictable\, show u
 nprecedented conformational stability\, and represent convenient building 
 blocks to elaborate synthetic\, very large (protein-sized) folded architec
 tures. This lecture will give an overview of our current efforts to design
  abiotic tertiary structures based on aromatic scaffolds\,[1] to prepare a
 nd select (as opposed to design) aromatic foldamer-peptide hybrid architec
 tures\,[2\,3] and to use aromatic foldamers to recognize sizeable protein 
 surfaces.[4\,5]\n\n\nReferences:\n\n[1]	S. De et al.\, Designing cooperati
 vely folded abiotic uni- and multimolecular helix bundles\, Nat. Chem. 201
 8\, 10\, 51.\n[2]	J. M. Rogers\, S. Kwon et al. Ribosomal synthesis and fo
 lding of peptide-helical aromatic foldamer hybrids\, Nat. Chem. 2018\, 10\
 , 405.\n[3]	M. Kudo\, V. Maurizot\, B. Kauffmann\, A. Tanatani\, I. Huc\, 
 Folding of a linear array of a-amino acids within a helical aromatic oligo
 amide frame\, J. Am. Chem. Soc. 2013\, 135\, 9628.\n[4]	K. Ziach\, C. Chol
 let\, et al.\, Single helically folded aromatic oligoamides that mimic the
  charge surface of double-stranded B-DNA\, Nat. Chem. 2018\, 10\, 511.\n[5
 ]	M. Jewginski\, T. Granier\, B. Langlois d’Estaintot\, L. Fischer\, C. 
 D. Mackereth\, I. Huc\, Self-assembled protein-aromatic foldamer complexes
  with 2:3 and 2:2:1 stoichiometries\, J. Am. Chem. Soc. 2017\, 139\, 2928\
 n
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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