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SUMMARY:Fluid dynamics and development of orientational polarity in multic
 iliated tissues  - Francesco Boselli (University of Cambridge)
DTSTART:20190627T120000Z
DTEND:20190627T130000Z
UID:TALK126925@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:During embryonic development\, the orientation of motile cilia
  is established in part through the action of hydrodynamic forces\, but a 
 direct test of this mechanism has remained outstanding. Using multiciliate
 d cells on the larval skin of Xenopus laevis\, the role of fluid flow in d
 evelopment of cilia orientational polarity is investigated by a combinatio
 n of live fluorescence imaging of the ciliated tissue\, high-speed cilia i
 maging\, microfluidics\, and quantitative flow visualization.\n\nFirst\, a
  systematic description of the flow profile about a multiciliated cell in 
 vivo is presented\, revealing the underling mechanical forces. Second\, th
 e live response of the system to hydrodynamic forces is tested by applying
  an exogenous flow. At the cell scales\, basal bodies increase their align
 ment following cell shape changes and cytoskeleton remodelling. At the tis
 sue scale\, cell flows lead to tissue shear and overall changes in cell or
 ientation refining the alignment of ciliated cells.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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