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SUMMARY:LMB Seminar Series - Antibodies against Ebola and Lassa: A Global 
 Collaboration - Erica Ollmann Saphire\, Professor Department of Immunology
  and Microbiology California Campus
DTSTART:20190723T100000Z
DTEND:20190723T110000Z
UID:TALK127309@talks.cam.ac.uk
CONTACT:72112
DESCRIPTION:The Ebolavirus genus includes several viruses that are highly 
 pathogenic in humans and cause periodic episodes of lethal disease\, inclu
 ding a currently persisting outbreak in the Democratic Republic of the Con
 go. Lassa virus\, an arenavirus\, is endemic in West Africa and causes up 
 to 300\,00 infections annually with disease similar to that of the ebolavi
 ruses. Both Lassa and the Ebolaviruses display a single trimeric glycoprot
 ein\, which is the primary target for protective antibody responses. Struc
 tural analyses of the glycoprotein in complex with protective antibodies f
 rom human survivors illuminates how an immune response ca be successful ag
 ainst these viruses and provides a roadmap for therapeutic interventions. 
 A multidisciplinary\, global collaboration bridging X-ray crystallography 
 and cryoEM to field work in endemic sites in Africa led to the identificat
 ion of unusual molecules of broader specificity and activity and the devel
 opment of several therapeutic strategies where none existed before.    \n\
 n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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