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SUMMARY:LMB Seminar Series - Organelle contact sites: a new layer in the o
 rganization of Eukaryotic cells - Benoit Kornmann\, Associate professor 
 – Dept. of Biochemistry\, Oxford University\, and C.W. Maplethorpe Tutor
 ial Fellow in Bio-chemistry – St-Hugh’s College\, Oxford University
DTSTART:20190912T093000Z
DTEND:20190912T103000Z
UID:TALK127312@talks.cam.ac.uk
CONTACT:72112
DESCRIPTION:Intracellular organelles constitute dense and branched membran
 e networks that are under constant remodeling. My lab is interested in how
  these organelle networks are generated\, distributed and regulated. We al
 so investigate how this networked morphology is related to the organelle's
  activity. \nThese highly extensive and dynamic networks cohabit in the ex
 tremely crowded cytoplasmic space. This situation leads to unwanted collis
 ions and entanglements that needs to be resolved. We show that\, in the ca
 se of mitochondria\, these collisions and entanglements can be resolved by
  mitochondrial fission. Mechanical forces applied to mitochondrial tubules
  lead to the recruitment and activation of the mitochondrial fission machi
 nery\, leading to the resolution of entanglements. These results imply tha
 t a biochemical response can be triggered by a mechanical stimulus and tha
 t forces within the cells participate in the shaping of organelles.\nThe e
 xtended morphology of several organelles might allow them to contact each 
 other to exchange lipid molecules. Because most of the factors involved in
  lipid exchange are unclear or unknown\, we developed a novel method that 
 uses transposons and next-generation sequencing to interrogate the yeast g
 enome and map in a single step all proteins and protein domains necessary 
 for growth in a given condition. We use it to identify redundancies in lip
 id exchange routes\, but the power of the method finds myriad of applicati
 ons far beyond our usage. \n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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