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SUMMARY:Role of extracellular vesicles in helminth-host interactions: From
  immunomodulation to vaccine development - Dr Javier Sotillo-Gallego (Inst
 ituto Carlos III\, Madrid)
DTSTART:20191023T150000Z
DTEND:20191023T160000Z
UID:TALK127375@talks.cam.ac.uk
CONTACT:Theodora Anderson
DESCRIPTION:Helminths secrete a variety of molecules implicated in host-pa
 rasite interactions\, either as soluble molecules or packed within extrace
 llular vesicles (EVs). These EVs can be categorised in exosomes\, microves
 icles or apoptotic bodies depending on their size and origin\, and can har
 bour many different proteins\, lipids\, glycans and genetic material such 
 as miRNAs and mRNAs. Helminth-derived EVs\, particularly exosome-like vesi
 cles\, have been shown to interact with the host in many different ways. T
 hey can be internalised by a variety of cells including immune cells such 
 as macrophages and dendritic cells\, as well as by intestinal cells\, and 
 liver cells\; and can promote or inhibit the secretion of different cytoki
 nes. EVs secreted by some nematodes and trematodes have a potent immunomod
 ulatory effect\, and can ameliorate the symptoms of chemically-induced col
 itis in mice. Furthermore\, EVs from different helminths contain vaccine c
 andidates\, showing the potential of EVs to be used as a source to develop
  new control strategies against helminth infections. \n\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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