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SUMMARY:MHC-independent thymocyte selection\, is it possible?  - Prof. Syl
 vie Lesage\; The Maisonneuve-Rosemont Hospital Research Centre\, Montreal\
 , Canada
DTSTART:20191007T110000Z
DTEND:20191007T120000Z
UID:TALK127603@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:T cells are selected on the thymus on class I and class II MHC
  molecules to respectively yield conventional CD8+ and CD4+ T cells. The C
 D4 and CD8 co-receptors are thought to be involved in the thymocyte select
 ion process\, by facilitating both TCR binding to the respective MHC molec
 ules as well as TCR signalling. Over the past decade\, we have been invest
 igating T cells that lack both CD4 and CD8 co-receptor expression\, which 
 have been dubbed double negative (DN) T cells. In this presentation\, I wi
 ll discuss our most recent observations regarding the thymic selection pro
 cess of DN T cells. We have identified a unique thymic selection process f
 or DN T cells\, on the opposite spectrum to agonist selection. Our results
  suggest that an MHC-independent thymic selection can yield functional imm
 unoregulatory DN T cells. 
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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