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SUMMARY:The Nutrition and Cancer Journey: from Chemical-Physical Carcinoge
 nesis to Metabolic Carcinogenesis. - Professor Elio Riboli\, MD\, MPH\, MS
 c\, Imperial College\, London
DTSTART:20191129T180000Z
DTEND:20191129T191000Z
UID:TALK127615@talks.cam.ac.uk
CONTACT:Ali Mashhadi
DESCRIPTION:A growing body of scientific evidence has accumulated supporti
 ng the role in cancer aetiology of factors often labelled as “metabolic
 ”\, including diet\, anthropometry\, physical activity and metabolic syn
 drome components. To study these factors\, we established EPIC (European P
 rospective Investigation into Cancer) in collaboration with researchers in
  10 European countries and enrolled 521\,000 participants (http://epic.iar
 c.fr/).  EPIC contributed to the identification of the role of overweight\
 , obesity and physical inactivity in increasing cancer risk\, particularly
  for cancer of the colon and rectum\, gastric cardia\, oesophagus (adenoca
 rcinoma)\, breast (after menopause)\, endometrium\, ovary\, kidney\, liver
 \, gallbladder\, and pancreas.  The mechanisms linking diet\, obesity and 
 physical inactivity with cancer are not fully understood\, however there a
 re promising research lines including insulin sensitivity deregulation\, t
 riggering of inflammation processes\, deregulation of various tissue growt
 h factors and cell cycle. The obesity\, insulin resistance  and cancer ass
 ociation has been recently corroborated by the results of mendelian random
 ization analyses showing that genetic variants predicting obesity or insul
 in resistance  also predict higher risk of cancers of the colon\, rectum a
 nd breast. Overall\, diet\, obesity and sedentary lifestyle have emerged a
 s major worldwide causes of cancer\, other chronic diseases as well as of 
 premature death. This knowledge paves the way to new opportunities for pri
 mary and secondary cancer prevention. \n\nThis event is jointly organised 
 by the Wolfson College Science Society and the Wolfson College Society of 
 Emeritus Fellows.
LOCATION:Wolfson College - The Lee Hall
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