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SUMMARY:Organoids: closing the gap between in vitro &amp\; in vivo models 
 - Professor Jerry Wells (Wageningen University &amp\; Research)
DTSTART:20200115T160000Z
DTEND:20200115T170000Z
UID:TALK128128@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Over the past decade\, technological advances have enabled lon
 g-term culture of organotypic intestinal tissue derived from human subject
 s and from human pluripotent stem cells. These in vitro culture systems ha
 ve already shown considerable promise for informing our understanding of o
 rgan development and function. Additionally\, organoids provide a means to
  better understand individual variation in response to drugs or infections
 . The generation of organoids from livestock and other animals it an emerg
 ing field of research with high potential for applications in animal scien
 ce and veterinary medicine.\nHere we show that location-specific functions
  of different parts of the intestine are intrinsically programmed in the a
 dult stem cells of the porcine intestinal epithelium. \n\nRecent data on t
 he stability of intestinal tissue organoids during long-term culture will 
 also be summarized. Finally\, examples of the use of these tools in the st
 udy of host–pathogen interactions and other future avenues of research w
 ill be presented.\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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