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SUMMARY:Ageing and dementia risk-related brain differences in the cognitiv
 ely healthy: Evidence from multi-modal MRI - Dr Claudia Metzler-Baddeley\,
  Senior Lecturer in Cognitive Neuroscience\, Cardiff University
DTSTART:20190912T113000Z
DTEND:20190912T123000Z
UID:TALK128269@talks.cam.ac.uk
CONTACT:Dr Muzaffer Kaser
DESCRIPTION:As the global population is ageing\, the number of older peopl
 e affected by conditions leading to dementia such as Alzheimer’s disease
  (AD) is increasing. As AD pathology is thought to accumulate over many ye
 ars before the onset of cognitive impairments\, it may be possible to iden
 tify early warning signs associated with dementia risk so that asymptomati
 c individuals at heightened risk can be stratified into future clinical tr
 ials for novel preventative therapeutics. \nThe objective of the Cardiff A
 geing and Risk of Dementia Study (CARDS) (Metzler-Baddeley et al. 2019a\,b
 ) is to investigate the impact of ageing and genetic and lifestyle risk fa
 ctors\, i.e. APOE4 genotype\, Family History (FH) of dementia and central 
 obesity\, on the brain and cognition in asymptomatic individuals. This was
  done in 166 cognitively healthy adults (38-71 years of age) using non-inv
 asive\, multi-parametric magnetic resonance imaging (MRI). More specifical
 ly\, multi-component diffusion-based Neurite Orientation Density and Dispe
 rsion Imaging (NODDI) (Zhang et al 2012) was employed to gain metrics of n
 eurite microstructure (apparent neurite density\, orientation dispersion\,
  and free water tissue content) and quantitative Magnetization Transfer (q
 MT) (Sled 2018) and T1-relaxometry were used to gain metrics that are sens
 itive to myelin and inflammation [macromolecular proton fraction (MPF)\, f
 orward exchange rate kf\, R1). Ageing was associated with a reduction of M
 PF\, kf\, and R1 and increases in free water signal and orientation disper
 sion in white and grey matter but no differences in apparent axon density.
  Furthermore\, synergistic effects of FH\, APOE and Waist Hip Ratio were o
 bserved in white and grey matter MPF and in grey matter kf. These results 
 are consistent with neuropathological evidence of age-related loss of myel
 in rather than axons. They also suggest that genetic and lifestyle risk fa
 ctors adversely impact myelination. These results will be discussed in lig
 ht of a glia model of ageing and neurodegeneration (Bartzokis 2011).
LOCATION:Seminar Room\, Herchel Smith Building\, Forvie Site.
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