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SUMMARY:On Nucleic Acid Feedback Controllers - Nuno Paulino\, University o
 f Warwick
DTSTART:20191128T140000Z
DTEND:20191128T150000Z
UID:TALK128644@talks.cam.ac.uk
CONTACT:Alberto Padoan
DESCRIPTION:Implementations of nucleic acid chemistry and DNA strand displ
 acement reactions have demonstrated their capacity to perform analogue sig
 nal processing\, to drive molecular nanomachines\, and to operate “in vi
 vo” in mammalian cells. The expanding field of DNA nanotechnology  makes
  nucleic acids promising candidates to embed synthetic feedback control ci
 rcuitry in biomolecular environments.\n \nTheoretical frameworks are now a
 vailable to represent feedback control systems as chemical reaction networ
 ks which can be readily translated into equivalent nucleic acid-based chem
 istry. To date\, the design of feedback control systems within this framew
 ork has been restricted to simple proportional-integral controller archite
 ctures. In this seminar I describe how the framework may be expanded to re
 alise both proportional-integral-derivative and state feedback controllers
 \, and verify their correct implementation in nucleic acid-based chemistry
  using the VisualDSD simulation package.\n \nI also show how a number of t
 ools for the rigorous robustness analysis of feedback control systems may 
 be applied in the context of nucleic acid-based controllers. The “dual-r
 ail representation” with chemical reactions employed in this framework i
 ntroduces additional nonlinear dynamics\, even when applied to linear syst
 ems\, which must be considered when analysing the stability properties of 
 controllers to experimental uncertainty. The seminar demonstrates how the 
 structured singular value (µ) analysis tool can be extended to evaluate t
 he robustness of this class of systems and uncover worst-cases missed by M
 onte Carlo simulations.
LOCATION: Cambridge University Engineering Department\,  Seminar Room JDB
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