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SUMMARY:Determining the mechanism underlying retrieval-extinction: reconso
 lidation or extinction? - Eloise Kuijer - Masters Student\, Department of 
 Psychology\, Cambridge
DTSTART:20190812T120000Z
DTEND:20190812T130000Z
UID:TALK128863@talks.cam.ac.uk
CONTACT:Lorraine Coulson
DESCRIPTION:Maladaptive associations are fundamentally involved in drug ad
 diction and relapse. Different therapies exist to combat these association
 s in order to decrease the burden of addiction. One potential non-pharmaco
 logical approach is prolonged exposure (extinction) therapy\, however\, th
 is is inefficacious for addiction. A new approach may be provided by ‘ex
 tinction within the reconsolidation window’ or ‘retrieval-extinction
 ’\, in which a temporally isolated retrieval session shortly before exti
 nction can strengthen its effect and thus decrease relapse. Currently\, it
  is unknown whether this retrieval session affects the memory updating rec
 onsolidation or enhances the novel negative competing extinction memory. W
 e sought to examine the underlying mechanism in a behavioural rat model of
  cocaine addiction undergoing retrieval-extinction. In order to test if re
 trieval-extinction depends on reconsolidation or extinction\, we targeted 
 the unique destabilisation phase of reconsolidation with administration of
  nimodipine\, an L-type Voltage Gated Calcium Channel inhibitor. 
LOCATION:Kenneth Craik Room\, Craik Marshall Building\, Downing Site\, Cam
 bridge
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