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SUMMARY:Adaptation for life on land – remodelling the pharynx in develop
 ment and evolution - Professor Anthony Graham\, King's College London
DTSTART:20191009T120000Z
DTEND:20191009T130000Z
UID:TALK129094@talks.cam.ac.uk
CONTACT:Toby Andrews
DESCRIPTION:The pharynx is an important region of the vertebrate body that
  is involved in many key processes including feeding\, respiratory and vas
 cular functions\, immune and endocrine activities. However\, with the colo
 nisation of land by vertebrates\, the pharynx underwent substantial modifi
 cation. In this talk\, I will discuss the development of the pharynx and h
 ow this has been altered to facilitate terrestrial life. To understand how
  the development of the pharynx has been modified through evolution\, we t
 ake a comparative approach. This involves analysing pharyngeal development
  using a range of cellular and molecular approaches: immunostaining\, in s
 itu hybridisation\, morpholino knockdowns\, lineage tracing and pharmacolo
 gical inhibition of signalling pathways\, in embryos that are chosen for t
 he phylogenetic position. We have considered how several features have bee
 n altered. The gills and their covering\, the operculum\, have been lost a
 nd the number of embryonic segments reduced. Yet new structures such as th
 e parathyroid glands and larynx have also emerged. Our work is significant
  as it lays out the developmental changes that underpinned these alteratio
 ns. It further highlights the progressive nature of evolutionary change an
 d shows that the modifications underpinning the emergence of the tetrapods
  were not as abrupt as previously believed. 
LOCATION:Part II Lecture Theatre\, Department of Zoology
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