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SUMMARY:Left-right asymmetric cell intercalation drives directional collec
 tive cell movement in epithelial morphogenesis - Katsuhiko Sato (Hokkaido 
 University)
DTSTART:20190913T120000Z
DTEND:20190913T130000Z
UID:TALK129436@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:During early development and wound healing\, epithelial cells 
 (cohesive cells) that form a monolayer sheet sometimes move collectively i
 n a definite direction in the sheet\; that is\, the cohesive cells move un
 idirectionally while maintaining the attachments with adjacent cells. \nTh
 is phenomenon is called collective migration of epithelial cells [1]\, and
  is considered to be an essential factor for morphological changes of mult
 icellular organisms [2]. While the molecular mechanisms underlying this ph
 enomenon are becoming understood\, much of the mechanical mechanisms remai
 n still unclear. In the present talk\, I will provide one possible mechani
 sm for collective migration from a theoretical point of view [3]: If the c
 ell boundaries contract depending on their orientation (planar polarity)\,
  and spatial inhomogeneity about the cell properties\, such as strength of
  cell adhesion\, exists\, then the cohesive cells collectively move in the
  direction perpendicular to that of spatial inhomogeneity\, by repeating r
 earrangement of neighbor relationships. I will demonstrate this scenario b
 y using the vertex model\, and reproduce the behaviors of typical collecti
 ve cell migration such as that seen in zebrafish lateral line primordium. 
 I also provide experimental evidence for this type of movement by investig
 ating a phenomenon in development of fly\, where monolayer epithelial shee
 ts move 360 degrees clockwise around the genital disc [4].\n\nRefs:\n1. P.
  Friedl and D. Gilmour\, (2009) Nat. Rev. Mol. Cell Biol. 10\, 445-457.\n2
 . J. Davies\, Mechanisms of Morphogenesis (Academic Press\, Second Edition
 \, 2013).\n3. K. Sato\, T. Hiraiwa\, and T. Shibata\, Phys. Rev. Lett. 115
 \, 188102 (2015).\n4. K. Sato\, T. Hiraiwa\, E. Maekawa\, A. Isomura\, T. 
 Shibata\, and E. Kuranaga\, Nat. Commun. 6\, 10074 (2015).
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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