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SUMMARY:What drives the dependence of human germline mutation rates on sex
 \, age\, and time?  - Professor Molly Przeworski\, Columbia University\, 
 New York 
DTSTART:20191017T130000Z
DTEND:20191017T140000Z
UID:TALK129493@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Germline mutation is the source of all heritable differences a
 nd therefore of fundamental importance. In mammals\, we know from longstan
 ding analyses of phylogenetic patterns on the X-chromosome and autosomes\,
  and from recent studies of human pedigrees\, that most mutations come fro
 m fathers\, and more are transmitted from older parents than from younger 
 ones. The textbook view is that these patterns reflect replication errors\
 , as there are both more mutations and more cell divisions in the male tha
 n in the female germline. I will present multiple lines of evidence that c
 all this view into question. I will argue instead that current data are be
 st explained by a much larger role of maternal age and DNA damage in the g
 enesis of germline mutations than previously appreciated\, and draw implic
 ations for why mutation rates depend on sex and age and how they evolve ov
 er time.
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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