BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Centrosome amplification and cancer: reaching out - Dr Susana Godi
 nho\, Barts Cancer Institute\, University of London
DTSTART:20191114T140000Z
DTEND:20191114T150000Z
UID:TALK129496@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:The centrosome is the main microtubule-organising centre in an
 imal cells\; important to assemble a bipolar mitotic spindle ensuring prop
 er chromosome segregation and genomic stability. Centrosomal abnormalities
 \, in particular centrosome amplification\, are recurrent features of huma
 n tumours. Enforced centrosome amplification in vivo plays a role in tumou
 r initiation and progression. However\, centrosome amplification occurs on
 ly in a subset of cancer cells and thus\, partly due to this heterogeneity
 \, the contribution of centrosome amplification to tumours in unknown. We 
 recently demonstrated that supernumerary centrosomes induce a paracrine-si
 gnalling axis via the secretion of proteins\, which leads to non-cell auto
 nomous invasion. This extra centrosomes-associated secretory phenotype (EC
 ASP) is a consequence of a stress response caused by increased reactive ox
 ygen species (ROS) in these cells. Furthermore\, increased ROS not only dr
 ives secretion of pro-invasive factors\, but also of small extracellular v
 esicles that change fibroblasts. We are now characterising this diverse se
 cretory phenotype and its impact not only in cancer cells but in the surro
 unding microenvironment. The discovery that cells with extra centrosomes c
 an manipulate the surrounding cells highlights unforeseen and far-reaching
  consequences of these abnormalities in cancer. 
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
END:VEVENT
END:VCALENDAR