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SUMMARY:The use of multi-parametric maps (MPMs) in ageing research - Wikto
 r Olszowy\, CHUV Lausanne
DTSTART:20200221T123000Z
DTEND:20200221T133000Z
UID:TALK129574@talks.cam.ac.uk
CONTACT:Rik Henson
DESCRIPTION:NB UNUSUAL FRIDAY SLOT\n\nRecent advances in image acquisition
  and image processing make it relatively easy to acquire high-resolution M
 RI maps that strongly correlate with iron\, myelin and tissue-free water c
 ontents. These maps are often called multi-parametric maps (MPMs) and the 
 methodology is regarded as a form of non-invasive in vivo histology. In th
 is talk\, first I will make an overview of studies showing good agreement 
 between histological and MPM age-related findings. Then\, I will discuss h
 ow age-related changes in microstructure can confound standard voxel-based
  morphometry (VBM) analyses\, and how this can be overcome using MPMs. Mor
 eover\, I will present my recent work comparing two MPM protocols: with 1m
 m and 1.5mm isotropic voxels\, respectively. For the higher resolution\, t
 he whole-brain acquisition takes 26 minutes\, while for the lower resoluti
 on the whole-brain acquisition takes 12 minutes. I found that in terms of 
 sensitivity to age-related differences\, the two protocols are very simila
 r. Finally\, I will discuss how the higher resolution maps can help deline
 ating small brain structures.
LOCATION:Lecture Theatre\, MRC Cognition and Brain Sciences Unit\, 15 Chau
 cer Road\, Cambridge
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