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SUMMARY:Development of the www.EcoliHub.org Information Resource and new a
 pproaches for studying the E. coli model cell - Prof Barry L Wanner\, Purd
 ue University\, West Lafayette\, IN 47907\, USA
DTSTART:20080725T150000Z
DTEND:20080725T160000Z
UID:TALK12967@talks.cam.ac.uk
CONTACT:M. Madan Babu
DESCRIPTION:This seminar will cover two independent topics – bioinformat
 ics and experimental biology. The first\npart will focus on the EcoliHub p
 roject. The second will cover recent work on dynamic localization of membr
 ane proteins to the poles of the E. coli cell.\n\nEcoliHub: We envision a 
 future where a dynamic community of online resources (both information and
  computational resources) acts cooperatively\, with each resource focusing
  on its strength and expertise\, and linking to the strength and expertise
  of other resources. This vision of collaboration and sharing is part of a
  suite of strategies that are collectively now referred to as Web 2.0. Eco
 liHub will not replace existing information resources\; the goal is to add
  value to these resources by: 1) improving the ability to share informatio
 n and computational services\namong resources\, 2) allowing resources to b
 e combined (piped together) in new ways\, without\nrequiring additional de
 velopment effort by the provider\, 3) improving the community’s ability 
 to\nfind information and resources\, 4) providing new information and reso
 urces that 'fill in the gaps'\nbetween existing resources and improve the 
 quality of information provided by all participating\nE. coli resources. T
 he current status of the EcoliHub project will be described.\n\nPolar loca
 lization: About E. coli 100 proteins appear to be specifically localized t
 o the ends\n(poles) of an E. coli cell. In collaboration with K. P. Ritchi
 e (a physicist)\, we are using\nfluorescent derivatives of membrane protei
 ns and epifluorescence microscopy to study the\nmovement of single molecul
 es inside living cells.
LOCATION:Structural Studies Coffee room\, MRC Laboratory of Molecular Biol
 ogy
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