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SUMMARY:Contact and non-contact methods for Long-Term Primary (from Retina
  Explants) and Secondary Cells Recording - K.S. Narayan\, Jawaharlal Nehru
  Center for Advanced Scientific Research\, Bangalore-560064\, India
DTSTART:20191004T100000Z
DTEND:20191004T110000Z
UID:TALK129715@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:The possibility of seamlessly integrating sense organs with de
 vice components and circuits consisting of soft electronic materials on bi
 ocompatible substrates offers useful options to monitor-enhance-augment na
 tural response to various stimuli. In this line of pursuit\, we have desig
 ned a 3-D Microfluidic device (MD) with the capability of auto bubble guid
 ance geometry in our laboratory which has recently been used to study long
 -term recordings from primary retina explant of chick embryo at different 
 stages of development. The unambiguous signature of the functioning of a d
 eveloped retina is the characteristic electroretinogram (ERG) waveform in 
 the multielectrode (MEA) recording and is utilized to demonstrate the effi
 cacy of the approach. Besides the MEA\, a remote\, non-contact sensor to e
 xtract signals at cellular levels in non-invasive manner is also demonstra
 ted. Signal elicited from developing retina (day-14 in absence of photorec
 eptors) upon photoexcitation of the underlying optoelectronic polymer subs
 trates is compared to response of mature retina (day-21). A general backgr
 ound and motivation for these studies will be presented.
LOCATION:Electrical Engineering\, Department of Engineering - CGC Seminar 
 Room\, 9 JJ Thomson Avenue\, Cambridge\, CB3 0FA
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