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SUMMARY:Melville Seminar : Broad-spectrum antiviral materials - Dr Samuel 
 Jones\, Dame Kathleen Ollerenshaw Fellow  University of Manchester
DTSTART:20190920T130000Z
DTEND:20190920T140000Z
UID:TALK129907@talks.cam.ac.uk
CONTACT:Allyson Walsh
DESCRIPTION:Antivirals currently only exist for 9 out of the 219 known hum
 an viral diseases\, are virus-specific and lose efficacy upon viral mutati
 on. A broad-spectrum antiviral\, the equivalent of broad-spectrum antibiot
 ics\, is needed\, especially in the fight against emerging viral outbreaks
 . Recent work has shown that highly sulfonated nanomaterials act in such a
  broad-spectrum antiviral manner due to multivalent interactions. This led
  to us producing the first ever fully-organic (sugar based) broad-spectrum
  virucidal antiviral and most recently synthetic polymer-based materials t
 hat also show broad-spectrum antiviral properties. These materials work vi
 a a newly proposed disruptive binding approach that effectively 'pops' the
  viral capsids. Evidence is provided by electron microscopy\, molecular dy
 namic simulations and in-vitro\, ex-vivo and in-vivo assays. My talk will 
 introduce the importance of developing new antivirals\, highlight the adva
 ntages to an extracellular virucidal approach and give examples of differe
 nt materials that we have shown can be produced with such antiviral proper
 ties. 
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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