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SUMMARY:Advanced polarized light microscopy for mapping molecular orienta
 tion - Prof Rudolf Oldenbourg\, Marine Biological Laboratory\, MA
DTSTART:20190924T083000Z
DTEND:20190924T100000Z
UID:TALK130099@talks.cam.ac.uk
CONTACT:Microsoft Research Cambridge Talks Admins
DESCRIPTION:Polarization is a basic property of light\, but the human eye 
 is not sensitive to it. Therefore\, we don’t have an intuitive understan
 ding of polarization-dependent phenomena.  However\, polarized light plays
  an important role in nature\, and polarization microscopy can be used to 
 understand molecular order in living cells\, tissues\, and whole organisms
 .  The talk will describe a polarized light microscope\, developed at the 
 Marine Biological Laboratory (MBL) in Massachusetts\, called the LC-PolSco
 pe. This instrument measures the orientation of molecules at every resolve
 d specimen point simultaneously. In addition to birefringence and diattenu
 ation\, it can also map the polarized fluorescence of fluorophores used to
  label structures like cell membranes and filaments. Recently\, these tech
 niques have been extended to multi-view microscopes. With a single-view mi
 croscope\, measuring the inclination angles of the optical axes of bonds\,
  particles\, and fluorophores with respect to the focal plane remains a ch
 allenge. Multi-view microscopes record images along several viewing direct
 ions\, thereby enabling unambiguous measurement of the three-dimensional o
 rientation of molecules and their aggregates
LOCATION:Auditorium\, Microsoft Research Ltd\, 21 Station Road\, Cambridge
 \, CB1 2FB
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