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SUMMARY:The making of AMPA-type glutamate receptors as instructed by their
  interactome - Prof Bernd Fakler\, University of Freiburg\, Germany
DTSTART:20190919T093000Z
DTEND:20190919T103000Z
UID:TALK130429@talks.cam.ac.uk
CONTACT:50507
DESCRIPTION:AMPA-type glutamate receptors (AMPARs)\, the key elements of f
 ast excitatory neurotransmission\, are fundamental for normal operation of
  the brain. These ionotropic receptors mediate a large part of the excitat
 ory postsynaptic currents (EPSCs) that drive point-to-point transmission i
 n glutamatergic synapses and control both propagation of the electrical si
 gnal and the influx of calcium ions into the postsynaptic spine. By these 
 means\, AMPARs promote formation and maturation of new synapses and trigge
 r a variety of activity-dependent processes that lead to alterations of bo
 th amplitude and properties of the EPSCs. In combination\, changes in sign
 al transduction and wiring are thought to endow excitatory neurotransmissi
 on with the activity-initiated plasticity that underlies learning and memo
 ry formation. I will discuss the molecular basis of some of the aforementi
 oned processes as encoded in the comprehensive proteome (or interactome) t
 hat we obtained with AMPARs isolated from the rodent brain. Particular emp
 hasis will be on the processes that determining the assembly of functional
  AMPAR complexes in native ER membranes and the impact of the receptor bio
 genesis on synaptic transmission and its activity-dependent dynamics.
LOCATION:Sanger Seminar Room\, MRC LMB\, Francis Crick Avenue\, CBC
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