BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Long-term dynamics of synapses and representations in the mouse au
 ditory cortex. - Prof Simon Rumpel\, Mainz University\, Germany
DTSTART:20190920T130000Z
DTEND:20190920T140000Z
UID:TALK130858@talks.cam.ac.uk
CONTACT:84523
DESCRIPTION:A traditional view of the healthy\, adult brain is that it has
 —after a period of developmental plasticity—reached a mature and highl
 y stable state. This stable state safeguards stable brain function and the
 refore plastic adaptations in brain circuits are typically only transientl
 y observed in response to external events\, such as learning-related memor
 y formation. However\, recent findings challenge this view and indicate th
 at neuronal circuits in the adult brain display a surprisingly high level 
 of intrinsic dynamics even under environmentally stable conditions. I will
  share data from chronic in vivo imaging studies in the auditory cortex of
  mice. At the connectivity level following individual synaptic connections
  and at the activity level monitoring functional cell assemblies over the 
 course of multiple days\, we observe substantial remodeling of the individ
 ual elements\, while global parameters such as synapse density or fraction
  of sound responsive cells are stably maintained. This indicates that neur
 onal networks operate in a dynamic equilibrium during basal conditions. Au
 ditory cued fear conditioning transiently disrupts this equilibrium and in
 troduces specific biases the dynamics of synapses as well as auditory repr
 esentations. Continuous\, intrinsic dynamics appear to be a fundamental pr
 operty of neural circuits and could endow them with computational abilitie
 s a fixed structure cannot offer.
LOCATION:James Dyson Building Seminar Room - Department of Engineering.
END:VEVENT
END:VCALENDAR