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SUMMARY:The function and evolution of motile DNA replication systems in ci
 liates - Nick Irwin\, University of British Columbia
DTSTART:20190924T090000Z
DTEND:20190924T100000Z
UID:TALK130936@talks.cam.ac.uk
CONTACT:46772
DESCRIPTION:\nDNA replication is a ubiquitous and conserved process. Howev
 er\, mechanistic exceptions exist that challenge our understanding of this
  system. This is exemplified by the replication band (RB) in spirotrich ci
 liates\, which is a motile hub that traverses the macronucleus while repli
 cating DNA. Here\, we used a combination of computational and experimental
  approaches to examine the function and evolution of the RB. We show that 
 the RB is paraphyletic due to its divergence in the spirotrich\, Phacodini
 um metchnikoffi. Rather than a band\, P. metchnikoffi contains a system we
  termed the replication envelope\, wherein replication initiates at the nu
 clear envelope and advances inwards in a centripetal wave. Furthermore\, w
 e identified genes involved in cellular transport that are associated with
  the RB and may be involved in its translocation. These findings reveal th
 e complex evolution of motile replication systems in ciliates and raise ne
 w possibilities for how nuclear organization can be regulated.
LOCATION:Department of Biochemistry\, Hopkins Building\, Stephenson Semina
 r Room
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