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SUMMARY:Biochemistry Friday Seminar - Putting the spotlight on the molecul
 ar choreography of viral RNAs - Dr Alex Borodavka
DTSTART:20200214T150000Z
DTEND:20200214T160000Z
UID:TALK131515@talks.cam.ac.uk
CONTACT:Alexander Borodavka
DESCRIPTION:Rotaviruses are highly contagious viruses that infect children
  worldwide\, causing >200\,000 deaths annually. A single infectious rotavi
 rus particle contains 11 unique RNA segments used to store its genetic mat
 erial\, serving as a multi-page instruction manual for building new virus 
 particles. It is a mystery how rotaviruses select and package 11 distinct 
 segments\, ensuring that each newly built virus has a complete set of inst
 ructions for infecting cells. Our lab uses a combination of single-molecul
 e imaging\, fluorescence spectroscopy and RNA structure probing tools to c
 rack the code of how rotaviruses select and package a complete set of 11 R
 NA segments. Understanding the mechanism of segment counting will accelera
 te our efforts to design improved rotavirus vaccines that offer greater pr
 otection\, and identify new targets for developing antiviral drugs.
LOCATION:Department of Biochemistry\, Sanger Building Jean Thomas Lecture 
 Theatre
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