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SUMMARY:How chromatin is spatially reorganised during zygotic reprogrammin
 g to totipotency - Dr Kikuë Tachibana\; Institute of Molecular Biotechnol
 ogy (IMBA)\, Austria
DTSTART:20191107T140000Z
DTEND:20191107T150000Z
UID:TALK131890@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:How chromatin is reorganised and reprogrammed after fertilisat
 ion to generate a totipotent embryo remain crucial questions in biology. O
 ne of our key interests is the mechanism of active DNA demethylation that 
 acts predominantly on the paternal genome of the single-cell embryo or zyg
 otes. To determine how 3D chromatin organisation changes towards a totipot
 ent state\, we pioneered single-nucleus Hi-C (snHi-C) and described the ch
 anges that occur during the oocyte-to-zygote transition. In order to fully
  understand zygote biology\, we also need to understand its precursor\, th
 e oocyte or egg. Chromosome missegregation in oocytes is the main cause of
  aneuploid pregnancies and spontaneous miscarriages. We are proposing a ne
 w hypothesis to explain the increase in chromosome missegregation that lea
 ds to trisomic pregnancies with maternal age.
LOCATION:Babraham - The Cambridge Building - Petersfield Lecture Theatre
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