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SUMMARY:Neurotransmitter spillover modulates neuronal information transmis
 sion - Mehrdad Salmasi (Ludwig-Maximilians-Universität\, Munich)
DTSTART:20191009T090000Z
DTEND:20191009T100000Z
UID:TALK132013@talks.cam.ac.uk
CONTACT:Yul Kang
DESCRIPTION:The neurotransmitter content of a vesicle outnumbers the recep
 tors on the postsynaptic density. Diffusion of neurotransmitter molecules 
 in the synaptic cleft can additionally activate the receptors of other act
 ive zones\, a phenomenon known as neurotransmitter spillover\, thereby mod
 ifying synaptic integration. In this study\, we investigate the effect of 
 neurotransmitter spillover on the rate of neuronal information transmissio
 n. We present an analytical model for spillover and derive the postsynapti
 c potential as a function of the number of released vesicles and the level
  of spillover. The target neuron receives input from synapses with multipl
 e release sites. Each site is modeled as a communication channel that has 
 a memory governed by short-term plasticity. The model captures synchronous
  spike-evoked and asynchronous release modes of the synapse. We calculate 
 the mutual information rate between the spiking activity of one input neur
 on and the target neuron\, and investigate the impact of the neuronal nois
 e\, short-term depression/facilitation\, and the clustering topology of th
 e release sites on the modulatory role of neurotransmitter spillover.
LOCATION:CBL Seminar Room (BE4-38\, http://learning.eng.cam.ac.uk/Public/D
 irections)
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