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SUMMARY:The axonal cytoskeleton at the nanoscale - Christophe Leterrier\, 
 Aix Marseille Université\, CNRS\, NeuroCyto\, Marseille\, France
DTSTART:20191202T163000Z
DTEND:20191202T180000Z
UID:TALK132067@talks.cam.ac.uk
CONTACT:Marisa Parsonage
DESCRIPTION:The intricate morphology and molecular identity of axons is ma
 intained for decades\, but also continuously adapts to changes in the envi
 ronment and activity of neurons. Axons fulfill these paradoxical demands t
 hanks to a unique cytoskeletal organization that ensures the coordinated t
 ransport\, anchoring and mobility of axonal components. In our lab\, we us
 e super-resolution microscopy to map the nanoscale architecture actin-base
 d structures within the axon. In the axon initial segment\, a key compartm
 ent for the maintenance of neuronal polarity\, we resolved a highly organi
 zed assembly encompassing the periodic actin/spectrin scaffold and its par
 tners: ankyrin\, myosins. We have also visualized new actin structures alo
 ng the axon shaft: rings\, hotspots and trails\, and are now exploring the
 ir molecular organization and functions. For this\, we develop a combinati
 on of versatile labeling\, correlative live-cell/super-resolution/electron
  microscopy and quantitative analysis that allow for high-content\, nanosc
 ale interrogation of the axonal architecture.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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