BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The Toxoplasma acrobat: combining biophysics and real time imaging
  to decode Toxoplasma top gliding performance - Dr Isabelle Tardieux\, Uni
 versité Grenoble
DTSTART:20200129T160000Z
DTEND:20200129T170000Z
UID:TALK132499@talks.cam.ac.uk
CONTACT:Ross Waller
DESCRIPTION:Among the eukaryote cells that navigate through fully develope
 d metazoan tissues\, the protozoan parasite Toxoplasma reaches one of the 
 highest speeds owing to a peculiar substrate-dependent type of motility kn
 own as helical gliding in endotherm metazoans’ tissues. This polarized c
 ell has evolved two unconventional myosinH and myosinA motors that success
 ively cooperate within their respective nano-machines\, called glideosomes
 \, to control the retrograde flow of apically and formin-nucleated actin f
 ilaments. While the\nmyosinA-glideosome lies in a space between the plasma
  membrane and a peculiar inner membrane complex\, it is thought to control
  the cortical forces during membrane flow and to\nbe a main component of t
 he motile force. However\, how forces and adhesions coordinate over the he
 lical gliding in metazoan’s tissues remains elusive. Combining quantitat
 ive\ntraction force and reflection interference microscopy with micro-patt
 erning and expansion microscopy we start to decode the Toxoplasma tachyzoi
 te rheology. We now unveil a pivotal role of a unique polar anchoring adhe
 sion in the development of the traction-springtorque triad forces that set
  the parasite thrust force required for high-speed helical gliding.
LOCATION:Seminar Room\, Department of Pathology
END:VEVENT
END:VCALENDAR