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SUMMARY:The remote control of gene expression: enhancer function in develo
 pment and disease - Wendy Bickmore\, MRC Human Genetics Unit\, Institute o
 f Genetics and Molecular Medicine\, University of Edinburgh
DTSTART:20201119T130000Z
DTEND:20201119T140000Z
UID:TALK132535@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Whilst we have the technical ability to sequence human genomes
  at scale\, we lack the knowledge to understand what most of that sequence
  does. Most of the human genome (>90%) does not contain protein-coding gen
 es and there are vast tracts of inter-genic space. Much of that genomic sp
 ace contains enhancers that regulate the expression of genes in time and s
 pace. In contrast to the 20\,000 or so genes in our genome\, there may be 
 hundreds of thousands\, or even millions\, of enhancers. Remarkably\, enha
 ncers can be found as far away as 1 megabase from the target gene whose ex
 pression they control\, and they can also be embedded in the introns of ot
 her genes several genes away from their target gene. In the face of this r
 egulatory complexity how can we understand the functional significance of 
 genetic variation in the non-coding genome?\nIt is hard to envisage how di
 stant enhancers function if one only considers the genome as a linear DNA 
 sequence. Rather\, three-dimensional chromatin folding in the nucleus must
  play a fundamental role in enhancer-promoter communication. I will descri
 be our work using different experimental approaches to investigate and man
 ipulate the three-dimensional folding of the mammalian genome at genetical
 ly defined long-range regulatory elements.\n
LOCATION:Join Zoom Meeting https://zoom.us/j/94186177151?pwd=ZHBhVVI2WUUwe
 ElydmlmYWZiN1FuQT09  Meeting ID: 941 8617 7151 Passcode: 426410
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