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SUMMARY:Transcriptional networks controlling blood stem cells - Dr. Bertie
  Gottgens (Cambridge Institute for Medical Research)
DTSTART:20081023T104000Z
DTEND:20081023T110500Z
UID:TALK13256@talks.cam.ac.uk
CONTACT:Duncan Simpson
DESCRIPTION:Conservation of the vertebrate body plan has been attributed t
 o the evolutionary stability of gene-regulatory networks. We have identifi
 ed a regulatory circuit made up of three genes and their enhancers that op
 erates during specification of blood stem cells in the mouse embryo. The t
 hree stem cell enhancers are bound by each of their transcription factors 
 and thus form a fully connected triad. One subcircuit of this network cons
 titutes the first example of any network motif operating during the specif
 ication of mammalian stem cells where all the individual components have b
 een identified. We are currently performing quantitative measurements of t
 he regulatory interactions within this subcircuit during the specification
  of early haematopoietic cells from differentiating embryonic stem cells. 
 Together with experimental information on protein complexes\, we are using
  these new quantitative measurements to build mathematical models for the 
 regulaory subcircuit to develop novel hypotheses for experimental validati
 on
LOCATION:Kaetsu Centre\, New Hall
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