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SUMMARY:Investigating human blood development at the single-cell level - A
 nna Maria Ranzoni - Wellcome - MRC Cambridge Stem Cell Institute/Wellcome 
 Trust Sanger Institute
DTSTART:20191205T131000Z
DTEND:20191205T140000Z
UID:TALK132607@talks.cam.ac.uk
CONTACT:David Gershlick
DESCRIPTION:Blood production during foetal development involves separate w
 aves of \nmigration of rare stem cells among different organs\, including 
 aorta\, \nliver and bones. It is still unclear how human foetal blood stem
  cells \narise\, expand and differentiate in the more than ten cell types 
 that \ncarry out vital body functions such as carrying oxygen\, clotting a
 nd \nfighting infections. In my research\, I utilise a variety of \ntechno
 logies\, including single-cell RNA sequencing\, whole genome \nsequencing 
 and cell-culture assays\, to characterise foetal blood \nprogenitors and t
 o understand how stem cells colonise the different \norgans during develop
 ment. Uncovering the dynamics of blood production \nin foetal development 
 has both biological and translational \nimplications. Foetal stem cells ha
 ve a higher regenerative potential \nthan their adult counterparts and stu
 dying them could provide important \ninsights on how we can mimic these pr
 operties in the production of blood \nstem cells ex-vivo for regenerative 
 medicine purposes.
LOCATION:The Richard King Room\, Darwin College
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