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SUMMARY:Wataching Molecules in Action - Professor Sir David Klenerman FRS 
 FMedSci\, Christ's College
DTSTART:20191030T173000Z
DTEND:20191030T190000Z
UID:TALK133468@talks.cam.ac.uk
CONTACT:Clare Kitcat
DESCRIPTION:A major advance in  the physical sciences in the last two deca
 des has been the development of quantitative methods to directly observe i
 ndividual molecules in solution\, attached to surfaces\, in the membrane o
 f live cells or more recently inside live cells. These single molecule flu
 orescence studies have now reached a stage where they can provide new insi
 ghts into important biological and biomedical  problems. After presenting 
 the principles of these methods\, he will give some examples from current 
 research. He has used single molecule fluorescence to detect and character
 ise the low concentrations of soluble protein aggregates that play a key r
 ole in the initiation and spreading of  Alzheimer’s disease. This provid
 es new insights into how  these aggregates damage neurons.  He will then d
 escribe how fundamental science aimed at watching single molecules incorpo
 rating nucleotides into DNA gave rise to a new rapid method to sequence DN
 A that is now widely used.
LOCATION:Yusuf Hamied Theatre\, Christ's College
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