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SUMMARY:The interplay between moving nuclei and membranes – interkinetic
  nuclear migration on the cell level - Anne Herrmann (University of Cambri
 dge)
DTSTART:20191024T120000Z
DTEND:20191024T130000Z
UID:TALK133567@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:In developing pseudostratified epithelia\, nuclei move repeate
 dly between the apical and basal surfaces of cells. This process is termed
  interkinetic nuclear migration (IKNM) and has been studied extensively in
  the brain\, retina and spinal cord of multiple organisms. But despite the
 se efforts many questions about the precise mechanism of IKNM remain. Base
 d on in vivo light sheet microscopy we previously developed a quantitative
  model for the phenomenological properties of IKNM on the tissue level. In
  this talk\, we now examine the properties of IKNM on the level of individ
 ual cells. First\, we investigate the random walk behaviour of individual 
 nuclei within the tightly packed tissue environment to make estimates of t
 he forces involved in this process. Secondly\, we aim to understand the ro
 le of the interaction between nucleus and cell membrane. This not only app
 ears to influence IKNM but possibly even has implications for the overall 
 cell architecture. 
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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