BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Insights from Correlations between Nanomaterials Design and Biolog
 ical Response - Ulrich Wiesner - Spencer T. Olin Professor of Engineering\
 , Cornell University\, USA
DTSTART:20191112T110000Z
DTEND:20191112T120000Z
UID:TALK133618@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Despite significant promise of nanomaterials in medicine\, few
  colloidal materials make the transition into the realm of human clinical 
 applications. To a large extend this is due to a lack of fundamental under
 standing of how nanomaterials design modulates biological response. In tur
 n\, this can often be related to unresolved heterogeneities in composition
 \, structure\, and surface chemical properties in nanomaterials synthesis 
 batches as compared to low molar mass compounds\, the current paradigm in 
 pharmaceutical treatments. In this presentation a novel class of ultrasmal
 l multifunctional fluorescent core-shell polymer-silica hybrid nanoparticl
 es will be introduced referred to as “Cornell dots” or simply “C dot
 s”. These particles have sizes below 10 nm\, i.e. below the threshold fo
 r renal clearance\, leading to favorable biodistributions and pharmacokine
 tics. Because of their small size which is of the order of a medium-size p
 rotein\, high resolution chromatographic techniques can be applied to thei
 r characterization\, opening up a new paradigm in establishing structure -
  biological response correlations. These smaller than 10 nm sized PEGylate
 d probes for nanomedicine are the first dual-modality (optical/PET) hybrid
  nanoparticles of their class and properties receiving investigational new
  drug (IND) FDA approval for first in-human clinical trials in the US.1 In
  this presentation\, results on C dot synthesis and characterization will 
 be reported with focus on materials properties that facilitate translation
  into clinical applications. This will include description of encouraging 
 results of the characterization of C dots with high-resolution chromatogra
 phic techniques like GPC and HPLC. It will also include the use of C dots 
 in unconventional therapeutic strategies against cancer involving the tumo
 r microenvironment (TME)\, as well as the discovery of novel silica nanopa
 rticle topologies.2\,3 The talk will finally discuss novel generation C do
 ts as amorphous quantum nanomaterials enabling exquisite control of their 
 quantum behavior under illumination leading to advanced materials for appl
 ications in optical super-resolution microscopy (SRM) and photodynamic the
 rapy.4\n\nReferences:\n1.)	E. Phillips\, O. Penate-Medina\, P. B. Zanzonic
 o\, R. D. Carvajal\, P. Mohan\, Y. Ye\, J. Humm\, M. Gönen\, H. Kaliagian
 \, H. Schöder\, H. W. Strauss\, S. M. Larson\, U. Wiesner\, M. S. Bradbur
 y\, Clinical translation of an ultrasmall inorganic optical-PET imaging na
 noparticle probe\, Sci. Transl. Med. 6 (2014)\, 260ra149.\n2.)	S. Eun Kim\
 , L. Zhang\, K. Ma\, M. Riegman\, F. Chen\, I. Ingold\, M. Conrad\, M. Z. 
 Turker\, M. Gao\, X. Jiang\, S. Monette\, M. Pauliah\, M. Gonen\, P. Zanzo
 nico\, T. Quinn\, U. Wiesner\, M. S. Bradbury\, M. Overholtzer\, Ultrasmal
 l Nanoparticles Induce Ferroptosis in Nutrient-Deprived Cancer Cells and S
 uppress Tumor Growth\, Nat. Nanotech. 11 (2016)\, 977–985\n3.)	K. Ma\, Y
 . Gong\, T. Aubert\, M. Z. Turker\, T. Kao\, P. C. Doerschuk\, U. Wiesner\
 , Self-assembly of highly symmetrical\, ultrasmall inorganic cages directe
 d by surfactant micelles\, Nature 558 (2018)\, 577-580.\n4.)	F. F. E. Kohl
 e\, J. A. Hinckley\, S. Li\, N. Dhawan\, W. P. Katt\, J. A. Erstling\, U. 
 Werner-Zwanziger\, J. Zwanziger\, R. A. Cerione\, U. B. Wiesner\, Amorphou
 s Quantum Nanomaterials\, Adv. Mater. 31 (2019)\, 1806993.\n
LOCATION:Electrical Engineering\, Department of Engineering - EED Seminar 
 Room - 9 JJ Thomson Avenue\, Cambridge\, CB3 0FA
END:VEVENT
END:VCALENDAR