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SUMMARY:Towards XNA molecularbiology: reinventing biology one protein at a
  time     - Dr Vitor Pinheiro
DTSTART:20200303T130000Z
DTEND:20200303T140000Z
UID:TALK133798@talks.cam.ac.uk
CONTACT:Florian Hollfelder
DESCRIPTION:Life on Earth\, despite its diversity\, is restricted to a nar
 row range of chemical reactions\, structures and materials. Although all l
 ife relies on DNA and RNA for their chemical information storage\, it is n
 ow clear that many other synthetic genetic materials (or XNAs) are possibl
 e and could functionally substitute DNA. Nevertheless\, DNA doesn’t func
 tion in isolation\,it is supported by a range of DNA binding proteins and 
 nucleic acid processing enzymes – none of which are available for XNA. W
 ith a view towards creating aviable XNA episome in vivo\, we have focused 
 on the systematic development of XNA processing enzymes\, primarily by dir
 ected evolution. My talk will present some of this trajectory as well as s
 ome of the tools and platforms that we have developed but that have wider 
 applications.
LOCATION:Department of Biochemistry\, Sanger Building\, Thomas Lecture The
 atre
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