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SUMMARY:Genetics of Axonal Mitochondrial Biology - Gaynor Smith\, Cardiff 
 University
DTSTART:20191113T173000Z
DTEND:20191113T193000Z
UID:TALK133900@talks.cam.ac.uk
CONTACT:Alexis
DESCRIPTION:Maintaining healthy mitochondrial populations in axons is esse
 ntial to sustain neuronal function\, and represents a major challenge for 
 neurons given the relative size of axons\, which in humans can be up to me
 ter long. Consequently\, deficits in mitochondrial function contribute to 
 a wealth of neurodegenerative diseases\, where axonal die back often prece
 des cell body demise. We know relatively little about the basic biology of
  axonal mitochondrial delivery\, maintenance and function in vivo. Here we
  describe novel\, genome-wide unbiased F1 forward genetic screen in Drosop
 hila for modifiers of mitochondrial populations in axons. We used the MARC
 M approach to fluorescently label homozygous mutants clones of glutamaterg
 ic sensory neurons and the mitochondria they contain\, in the translucent 
 adult Drosophila wing. This system allowed for the rapid assay mitochondri
 al morphology\, number\, and distribution in axons with single axon and si
 ngle mitochondrion resolution. We have discovered several mitochondrial mu
 tants that exhibit dramatic changes in mitochondria number and/or size. 
LOCATION:Gurdon Institute Tea Room
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