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SUMMARY:Milstein LMB Seminar Series: Stem Cells in Silence\, Action and Ca
 ncer  - Elaine Fuchs\, Rebecca C. Lancefield Professor Investigator\, Howa
 rd Hughes Medical Institute 
DTSTART:20200127T110000Z
DTEND:20200127T120000Z
UID:TALK134011@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Adult tissue stem cells have the ability to self-renew long te
 rm and differentiate into one or more tissues. Many stem cells are used sp
 aringly to replenish cells during normal homeostasis. However\, even stem 
 cells that are quiescent must be able to respond quickly to injury in orde
 r to fuel rapid tissue regeneration. How stem cells balance self-renewal a
 nd differentiation is of fundamental importance to our understanding of no
 rmal tissue maintenance and wound repair. The regulatory circuitry governi
 ng this normal balancing act is must be intricately regulated in normal ho
 meostasis\, and then transiently altered to cope with injury responses. In
 creasing evidence suggests that the mechanism goes awry in inflammation an
 d becomes hijacked in cancers. We use skin as a model to understand how th
 e microenvironment impacts the stem cells and their behavior in health and
  disease\, with the intent to unfold new avenues for therapeutics. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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