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SUMMARY:Transcription factors as sensors and modifiers of chromatin - Dr D
 irk Schübeler\; Friedrich Miescher Institute for Biomedical Research\, Sw
 itzerland
DTSTART:20191211T150000Z
DTEND:20191211T160000Z
UID:TALK134212@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Transcription factors only bind a minority of their motifs in 
 large mammalian genomes. One potential explanation is that many motifs are
  not accessible for binding due to the action of chromatin and DNA methyla
 tion. We are using mammalian stem cell models to understand this important
  interplay between gene regulation\, chromatin structure and DNA methylati
 on. We study the dynamics of the epigenome and test regulatory models in c
 ellular models by genetic perturbation and genome editing approaches.\n\nI
  will discuss our recent efforts in understanding how the sensitivity to D
 NA methylation can limit transcription factor binding in the context of th
 e cell and how TFs rely on specific chromatin remodelers for access to the
 ir binding sites.\n
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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