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SUMMARY:New tools for using single-molecule spectroscopy to elucidate biop
 hysical behavior - Professor Randall Goldsmith\, University of Wisconsin M
 adison
DTSTART:20191016T100000Z
DTEND:20191016T110000Z
UID:TALK134314@talks.cam.ac.uk
CONTACT:Dr Georg Krainer
DESCRIPTION:Single-molecule measurements are a powerful tool for unravelin
 g complex phenomena because unsynchronized dynamics can be directly monito
 red and heterogeneous properties directly revealed. I will show how new me
 thods allow the use of single-molecule measurements in increasingly challe
 nging environments and enable new insights. In the first section\, I will 
 describe the operation of a microfluidic trap that is capable of cancellin
 g Brownian motion\, allowing prolonged investigation of solution-phase spe
 cies\, as well as application to look at an intrinsically disordered prote
 in\, Tau\, at the center of the etiology of Alzheimer’s disease. In the 
 second section\, I will describe how nanophotonic devices can enable singl
 e-molecule measurements at record high concentration\, as well as an appli
 cation to understanding regulatory mechanisms in ion channels. In the thir
 d section\, I will describe a new and exceptionally fast idealization algo
 rithm for high throughput optical single-molecule experiments\, and applic
 ation to examination of ion channels.
LOCATION:Department of Chemistry\, Cambridge\, Todd Hamied Room
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