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SUMMARY:2019 Alkis Seraphim Memorial Lecture - “Hedgehog signaling: rege
 neration\, malignancy\, and regulation by membrane cholesterol redistribut
 ion” - Philip A. Beachy Ph.D.  Phil is currently the Ernest and Amelia G
 allo Professor in the Stanford University School of Medicine and a Profess
 or of Urology\, Developmental Biology and Chemical and Systems Biology.
DTSTART:20191118T170000Z
DTEND:20191118T183000Z
UID:TALK134323@talks.cam.ac.uk
CONTACT:45561
DESCRIPTION:The Hedgehog signaling pathway has critical roles in morphogen
 ic patterning of developing embryos\, and functions postembryonically to m
 aintain and repair adult tissues. In its embryonic patterning activities\,
  Hedgehog protein emanating from crucial organizing centers forms signalin
 g gradients that pattern adjacent fields of cells\, thus creating an indis
 pensable spatial coordinate system for the developing brain\, spinal cord\
 , somites\, limbs and other vertebrate organs. In its postembryonic regene
 rative functions\, the Hedgehog protein initiates reciprocal signaling bet
 ween the epithelium and mesenchyme to coordinate proliferation and differe
 ntiation of epithelial stem cells. In this lecture I will discuss my labor
 atory’s recent findings regarding this regenerative circuitry and its po
 tential manipulation for therapeutic purposes. At the molecular level\, I 
 will discuss newly discovered features of Hedgehog signal transduction via
  its receptor Patched\, which acts as a transmembrane cholesterol transpor
 ter\, and Smoothened\, a cholesterol-triggered mediator of pathway activat
 ion.
LOCATION:Department of Biochemistry\, Sanger Building\, Thomas Lecture The
 atre
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