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SUMMARY:Chromosomal evolution in Nematodes\, and other adventures on the T
 ree of Life - Professor Mark Blaxter\, Wellcome Sanger Institute\, Hinxton
 \, Cambridge 
DTSTART:20200528T130000Z
DTEND:20200528T140000Z
UID:TALK134401@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:In the Tree of Life programme at the Wellcome Sanger Institute
  we have embarked on a large scale mission to assist in the sequencing of 
 the genomes of all the planet’s biodiversity. Our focus is on eukaryotes
  (of all flavours - Metazoa\, Plantae\, Fungi and the polyphyletic “prot
 ists”). We are using long read (Pacific Biosciences\, Oxford Nanopore) a
 nd long range (HiC\, 10X genomics\, BioNano) to generate very high quality
  assemblies - wherever possible resolving to chromosomal molecules. We hav
 e two major current projects. The Wellcome-funded Darwin Tree iof Life pro
 ject is a collaboration with nine other organisations that aims to deliver
  the genomes of all species in Britain and Ireland. The Moore Foundation A
 quatic Symbiosis project\, just starting\, will collaborate globally to de
 liver genomes for a wide range of symbiont associations. I will introduce 
 our aims and methods and illustrate the kinds of data we intend to produce
  with some of our already-completed genomes.\nTo show what can be learnt f
 rom such chromosomal assemblies I will use an analysis of chromosomally-co
 mplete genomes from across the Rhabditida\, the order of nematodes that in
 cludes Caenorhabditis elegans. While the karyotype of these nematodes is r
 elatively stable\, we can describe a dynamic pattern of fission\, fusion a
 nd within chromosome rearrangement. The chromosome involved in sex determi
 nation (most species are XX:X0 female:male\, some are X:Y) can be traced b
 y the presence of a set of genes that are always on the X\, but the sex ch
 romosomes are frequently involved in fusion and fission events. We anticip
 ate similar findings\, where chromosomally-complete genomes permit resolut
 ion of complex patterns across the tree of life.
LOCATION:Zoom meeting
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