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SUMMARY:Unravelling mysterious interactions between viruses and antibodies
 : molecular mechanisms and importance in vaccination - Dr Sarah Caddy\, Se
 nior Research Fellow\, MRC Laboratory of Molecular Biology
DTSTART:20200122T160000Z
DTEND:20200122T170000Z
UID:TALK134497@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Neutralizing antibodies reduce infection by interfering with v
 iral entry. However\, non-neutralizing antibodies (nnAbs) also provide imm
 unity against diverse viruses including retroviruses\, arenaviruses\, infl
 uenza viruses and rotaviruses. The mechanism by which many of these nnAbs 
 provide protection has been a longstanding mystery. Our work shows that nn
 Abs can inhibit infection by engaging the cytosolic antibody receptor TRIM
 21 to result in a range of different outcomes.\n\nFor enveloped viruses\, 
 we have demonstrated that nnAbs can recruit TRIM21 to promote the inductio
 n of cytotoxic T cells. This highlights that cooperativity between both ar
 ms of adaptive immunity is crucial for successful resolution of viral infe
 ction\, and raises the possibility of new vaccine approaches.\n\nFor virus
 es with multiple capsid layers such as rotavirus\, intracellular antibodie
 s engage TRIM21 to target virus particles to the proteasome. We have shown
  that manipulation this pathway affects susceptibility to infection in a m
 ouse rotavirus model\, and propose that measuring these antibodies will pr
 edict vaccine efficacy. \n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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