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SUMMARY:Commensal E. coli are a reservoir for the transfer of XDR plasmids
  into epidemic fluoroquinolone-resistant Shigella sonnei - Prof. Stephen B
 aker\, Department of Medicine\, University of Cambridge
DTSTART:20200527T150000Z
DTEND:20200527T160000Z
UID:TALK134521@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Despite the sporadic detection of fluoroquinolone-resistant Sh
 igella in Asia in the early 2000s and subsequent global spread of ciproflo
 xacin-resistant (cipR) Shigella sonnei from 2010\, fluoroquinolones remain
  the recommended therapy for shigellosis. The potential for cipR S. sonnei
  to develop resistance to alternative second-line drugs may further limit 
 future treatment options. We aimed to understand the evolution of novel an
 timicrobial resistant (AMR) S. sonnei variants after introduction into Vie
 tnam. We found that cipR S. sonnei displaced the resident ciprofloxacin-su
 sceptible (cipS) lineage while rapidly acquiring additional resistance to 
 multiple alternative antimicrobial classes. We identified several independ
 ent acquisitions of XDR/MDR-inducing plasmids\, likely facilitated by hori
 zontal transfer from commensals in the human gut. By characterizing commen
 sal E. coli from Shigella-infected and healthy children\, we identified an
  extensive array of AMR genes and plasmids\, including an identical MDR pl
 asmid isolated from both S. sonnei and E. coli in the gut of a single chil
 d. We additionally found that antimicrobial usage may impact plasmid trans
 fer between commensal E. coli and S. sonnei.  These results suggest that i
 n a setting with high antimicrobial use and a high prevalence of AMR comme
 nsals\, cipR S. sonnei may be propelled towards pan-resistance by adherenc
 e to outdated international treatment guidelines.
LOCATION:Venue to be confirmed
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