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SUMMARY:Discovery and analysis of novel riboswitches - Professor Ronald Br
 eaker\, Yale University
DTSTART:20081106T160000Z
DTEND:20081106T170000Z
UID:TALK13480@talks.cam.ac.uk
CONTACT:3901
DESCRIPTION:Riboswitches are structured RNAs usually located in the untran
 slated regions (UTRs) of bacterial mRNAs that bind metabolites and control
  gene expression. Most riboswitches discovered to date sense fundamental m
 etabolites such as nucleobases and their derivatives\, coenzymes\, amino a
 cids and modified sugars. Thus\, researchers who seek to identify addition
 al riboswitch classes may benefit from searching for structured RNAs assoc
 iated with the mRNAs encoding metabolic enzymes for key biological compoun
 ds. We have recently used a bioinformatics strategy to discover several ri
 boswitch classes that sense coenzymes or their derivatives\, and our findi
 ngs suggest that many more riboswitches remain to be discovered. \n\nMost 
 recently\, we have identified the first examples riboswitches that sense a
  widespread bacterial second messenger. These riboswitches control the exp
 ression of numerous genes involved in virulence\, biofilm formation\, and 
 flagellar biosynthesis. The existence of such riboswitches indicates that 
 bacteria rely on riboswitches to make rapid changes in cellular physiology
 . Details regarding the discovery and analysis of novel riboswitch classes
  will be discussed.\n\nhttp://www.yale.edu/breaker/breaker.htm
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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